Chronic Myeloid Leukaemia in The 21st Century
نویسندگان
چکیده
Chronic Myeloid Leukaemia (CML) is a clonal, myeloproliferative disease that develops when a single, pluripotential, haemopoetic stem cell acquires the Philadelphia chromosome. CML was the first haematological malignancy to be associated with a specific genetic lesion. First recognised in 1 45, CML exhibits a consistent chromosomal abnormality in leukaemic cells, identified in 1960 by Nowell and Hungerford, termed the Philadelphia (Ph) chromosome. The cytogenetic hallmark of CML was identified in 1973 as the reciprocal translocation t(9;22)(q34:11). Furthermore, in 19 4, the ABL (Abelson) proto-oncogene was identified as being involved in this translocation. Breakthroughs in cancer biology have led to extensive characterisation of CML and it is now heralded as a ‘model’ of cancer.
منابع مشابه
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عنوان ژورنال:
- The Ulster Medical Journal
دوره 76 شماره
صفحات -
تاریخ انتشار 2007